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	Provedor de dados BJMBR (2) Autor Calafatti,S.A. (2) Marchioretto,M.A.M. (2) Ribeiro,M.L. (2) Bernasconi,G. (1) Bernasconi,G.C.R. (1) Cassiano,N.M. (1) Degger,M.F. (1) Deguer,M. (1) Ecclissato,C. (1) Ecclissato,C.C. (1) Mendonça,S. (1) Moraes,L.A. (1) Ortiz,R.A.M. (1) Pedrazzoli Jr,J. (1) Pedrazzoli Jr.,J. (1) Piovesan,H. (1) Silva,C.M.F. da (1) Mais... Palavra-chave Clarithromycin (1) Cytochrome P450 (1) Helicobacter pylori (1) Hepatitis C (1) Lansoprazole (1) Liver function (1) Metronidazole (1) Peptic ulcer (1) Pharmacokinetics (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2005 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of Helicobacter pylori infection and acid blockade by lansoprazole on clarithromycin bioavailability BJMBR Ortiz,R.A.M.; Calafatti,S.A.; Moraes,L.A.; Deguer,M.; Ecclissato,C.C.; Marchioretto,M.A.M.; Ribeiro,M.L.; Bernasconi,G.; Pedrazzoli Jr,J.. The effect of proton pump inhibitors and Helicobacter pylori infection on the bioavailability of antibiotics is poorly understood. We determined the effects of 5-day oral administration of 60 mg lansoprazole on the bioavailability of clarithromycin in individuals with and without H. pylori infection. Thirteen H. pylori-infected and 10 non-infected healthy volunteers were enrolled in a study with an open-randomized two-period crossover design and a 21-day washout period between phases. Plasma concentrations of clarithromycin in subjects with and without lansoprazole pre-treatment were measured by liquid chromatography coupled to a tandem mass spectrometer. Clarithromycin Cmax and AUC0-10 h were significantly reduced after lansoprazole administration. In... Tipo: Info:eu-repo/semantics/article Palavras-chave: Clarithromycin; Helicobacter pylori; Lansoprazole; Peptic ulcer; Pharmacokinetics. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300014 Plasma hydroxy-metronidazole/ metronidazole ratio in hepatitis C virus-induced liver disease BJMBR Marchioretto,M.A.M.; Ecclissato,C.; Silva,C.M.F. da; Cassiano,N.M.; Calafatti,S.A.; Mendonça,S.; Ribeiro,M.L.; Bernasconi,G.C.R.; Degger,M.F.; Piovesan,H.; Pedrazzoli Jr.,J.. It has been suggested that the measurement of metronidazole clearance is a sensitive method for evaluating liver function. The aim of this study was to evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole ratios as indicators of dynamic liver function to detect changes resulting from the various forms of chronic hepatitis C virus (HCV) infection. A total of 139 individuals were studied: 14 healthy volunteers, 22 healthy, asymptomatic, consecutive anti-HCV-positive HCV-RNA negative subjects, 81 patients with chronic hepatitis C (49 with moderate/severe chronic hepatitis and 34 with mild hepatitis), and 20 patients with cirrhosis of the liver. HCV status was determined by the polymerase chain reaction. Plasma concentrations of metronidazole... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metronidazole; Liver function; Hepatitis C; Cytochrome P450. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000300015 Registros recuperados: 2 Primeira ... 1 ... Última

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